When stand-up comedian Kumail (Kumail Nanjiani) is heckled by graduate student Emily (Zoe Kazan) at one of his shows, it leads to a flirtation, which leads to a one-night stand – and then, unexpectedly, to something more serious. But their blossoming relationship is about to hit two major roadblocks.
The first is Kumail’s parents, first-generation Pakistani immigrants who dote on their son but are determined that he will have a traditional arranged marriage. And the second is a mysterious illness which lands Emily in hospital, in a medically induced coma. As he waits anxiously by her side and wrestles with his doubts about their relationship, Kumail forms a bond with her parents (Ray Romano and Holly Hunter) which will change everything.